Aromatase Inhibitors for Breast Cancer

Aromatase Inhibitors (AI) do a great job treating Breast Cancers which are Estrogen dependent.  The AI wipe out all Estrogen thereby depriving the breast cancer of a needed stimulus. Unfortunately,...

Denosumab – Prolia – OPG Analog

Denosumab (Prolia) mimics the natural process that keeps OsteoClasts (the cells that gobble up bone) under control before menopause.  OsteoCytes release Osteoprotegrin (OPG) when Estrogen (or Testosterone) is on board....

A Delicate Balance

A delicate balance between bone formation and bone resorption is needed for Healthy Bone.  This balance is naturally present until menopause in a woman or “Low T” in a man....

Androgen Deprivation Therapy – ADT

Androgen Deprivation Therapy is used to treat Prostate Cancer.  ADT is usually effective against Prostate Cancer, adding years to a man’s life.  However, ADT can cause Osteoporosis and Fractures, UNLESS...

“Bisphosphonate Holiday” 2014

“You are entering a Data-Free Zone”   That was unfortunately the messasge at the joint meeting of the International Society for Clinical Densitometry (ISCD) and the International Osteoporosis Foundation (IOF) last month. ...

Interesting Medication Combinations from ASBMR

Studies of combinations of osteoporosis medications expanded at the American Society for Bone and Mineral Research (ASBMR) 2012.  Previous meetings featured alternating the anabolic, Teriparatide (Forteo) with a Bisphosphonate Antiresorptive, usually...

Prolia Is Now For Men Too!

The FDA has approved Prolia for men with osteoporosis, who are “at high risk for fracture”.  This affects a sizeable number of men.  High fracture risk includes men with crumbling...

Prolia for Men Too – A Few Men

Prolia has been available for postmenopausal women for 2 years.  It is the only Antiresorptive appropriate for persons with both reflux disease (GERD) and decreased renal function (mild kidney failure). ...

Osteoclasts Gone Wild Revisited

Osteoclasts are the cells that eat away bone.  Osteoclasts are normally kept under control by Estrogen in women and Testosterone in men.  Women lose Estrogen suddenly at Menopause.  Men lose Testosterone...