Rare cases of Osteonecrosis of the Jaw (ONJ) and Atypical Fractures of the Femur have been found in patients taking Alendronate. There is not yet any conclusive evidence that Alendronate, or any other Antiresorptive or Bisphosphonate, causes these conditions.
Alendronate is an Oral Bisphosphonate and has the same safety and effectiveness issues as others in this class. Read about these issues in the sections about Antiresorptives, Bisphosphonates, and Oral Bisphosphonates.
Alendronate is usually effective for preserving bone and preventing osteoporosis in patients who can tolerate it. Remember that it only works if you take enough Calcium and Vitamin D.
Jay Ginther, MD
2008 / Revised March 2011